The synthesis and formulation of high performing energetic materials is an ongoing mission for the DoD. Many factors have combined to impact the supply of these materials; some are unavailable domestically, the cost of others has become prohibitive, and many are now recognized as environmentally unacceptable having negatively impacted test and training ranges. Thus, new methods of synthesis and new formulations are required for continued DoD operations. This technical session explored novel methods for the synthesis and formulations of energetic materials that will lessen their environmental impact. Novel technologies will include continuous processing, reduction or elimination of heavy metals, as well as synthetic biology methods to produce precursors of energetic molecules. Taken together, this session explored and implement new, game-changing methods of synthesis and formulation that result in environmentally acceptable energetic formulations that have enhanced performance, longer range or more lethality.