Chlorinated solvents are prevalent contaminants in groundwater and soils at DoD sites. Of concern in recent years has been the migration of vapors from chlorinated solvent groundwater plumes into surface and sub-surface structures. The 2010 Technical Exchange Meeting on Vapor Intrusion brought together researchers, practitioners, and remedial project managers (RPM) dealing with vapor intrusion issues to provide a forum for interaction and exchange of knowledge on the current state of the science. The meeting highlighted the innovative studies being conducted under SERDP- and ESTCP-funded projects and encouraged discussion of pertinent issues faced by RPMs. The meeting also provided an opportunity for participants to visit a field laboratory, based in a residential building with a history of vapor intrusion impacts, where ESTCP technologies were being demonstrated.